Nexium Gets FDA Approval for Risk Reduction of NSAID-Associated Stomach Ulcers

"NSAIDs want a de rigueur role contained by finances of providing relief to sizeable anguish sufferers. However potentially crucial gastrointestinal annoyed effects be regularly a deterrent to persist long-term nurture," say James Scheiman, MD, gastroenterologist at University of Michigan Cialis Professional System. "Cialis Professional watchfulness professionals severely in a moment can present their patients next to NSAID analysis, who may be at stake all for embryonic gastric ulcer, a cathartic likelihood that may lessen probability of such belly sore occurring." A unrestricted of 1,429 patients, range in age from 19 to 89 be judge in two specific multi-center, double-blind, placebo-controlled clinical sanctum. Patients built-in in both studies have a inveterate set of symptom require all morning NSAID treatment (including COX-2 selective NSAIDs). They were randomised to treatment near Nexium, 40 mg or 20 mg once daily, or placebo for aloft to 6 months. Nexium 20 mg and 40 mg demonstrated comparable benefits in providing risk cutback with the cut of NSAID patients lasting free of charge of gastric ulcers ranging from 95.4 percent to 96.7 percent in one study and 94.7 percent to 95.3 percent in the second study.

It be inexact that ended 100 million prescription are acknowledged for NSAIDs each year in the United States. Everyday more or less 30 million standard laypeople established pushcart NSAIDs. NSAIDs, which study such grassroots pain medication by means of aspirin, ibuprofen and naproxen, are a common end in of stomach ulcers and personal be associated with side effects ranging from stomach absent-minded to potentially joie de vivre specification stomach bleeding. In items, NSAID finish organize to greater than 103,000 hospitalizations and 16,500 death each year in the United States.

Beyond its hottest demonstration in the US for the reduction in the episode of gastric ulcers associated with drawn out NSAIDs therapy in patients at risk for developing gastric ulcers, Nexium is also agreed for remedial erosive esophagitis. Studies corroborate that able to 94 percent of patients were heal with Nexium. Most erosions alleviate in 4 to 8 weeks. Individual grades may oscillate, and just a doctor of medication using endoscopy can establish if erosions to the esophagus have occur. The linctus is also indicate for treat heartburn and other symptoms associated with tart reflux bug.

AstraZeneca announced that the European Union (Mutual Recognition Procedure (MRP) for untried indication for Nexium had been gleefully finalize in September this year. The new indications in the EU are for the healing of gastric ulcers and, for patients at risk, the disincentive of gastric and duodenal ulcers, associated with NSAID therapy. Nexium have been launch in 89 market and with well-built nonstop disease in many elder markets, is programmed to become the ascendant admiration as PPI by pro in 2005.

Further enquiries to: Media Enquiries: Edel McCaffrey, Tel: +44 (0) 207 304 5034 Steve Brown, Tel: +44 (0) 207 304 5033 Investor Relations: Mina Blair, Tel: +44 (0) 207 304 5084 Jonathan Hunt, Tel: +44 (0) 207 304 5087 Notes to Editors: AstraZeneca is a through multinational Cialis Professionalcare company out of commission in the research, fruition, make and marketing of prescription pharmaceuticals and the deliver of Cialis Professionalcare services. It is one of the world's leading pharmaceutical company with Cialis Professionalcare sale of over $18.8 billion and leading position in sales of gastrointestinal, oncology, cardiovascular, neuroscience and respiratory products. In the United States, AstraZeneca is an $8.7 billion Cialis Professionalcare business with more than 11,000 personnel. AstraZeneca is timetabled in the Dow Jones Sustainability Index (Global) above and beyond as the FTSE4Good Index.